GENETIC-TAILORED NUTRIENT DELIVERY THROUGH GREEN NANOFIBERS

Abstract

While precision nutrition is a shift in paradigms for personalized healthcare, it still lacks integration with green technologies. This study presents a novel platform for green nanofibers, designed to deliver tailored micronutrients based on genetic predispositions. We synthesized and electrospun biodegradable nanofibers from plant-based polymers, zein, and pullulan. These fibers were infused with micronutrients, selectively tailored for gene–nutrient interaction pathways including MTHFR, FTO, and APOE. Advanced bioinformatics was applied to interpret nutrigenomic profiles and design nutrients at the molecular level, guiding their formulation. The designed nanofibers provided controlled-release properties that matched metabolic and absorption rates of xenobiotics specific to the user’s genotype. Nutrient bioavailability, relative to conventional delivery systems, was enhanced by up to 68%, as demonstrated by in vitro gastrointestinal simulations and cell-line uptake assays. Additionally, these processes showed a relative environmental footprint 72% lower than that of synthetic polymer carriers, verified through comparative life cycle assessment (LCA). This delivery system is environmentally friendly and responsive to the user’s genotype, bridging the precision health and materials science interface. It is particularly important for populations with non-communicable diseases related to diet, considering the altered genetic variability of nutrient requirements. This study explores multifunctional nutrition technologies by incorporating nutrigenomics, nanomaterials, and green chemistry into a singular platform for advanced preventive healthcare and sustainable wellness.